1. 个人简介：

毛泽斌，教授，主要从事细胞衰老与肿瘤的分子机理研究。在Aging，Aging cell, Oncogene等国际知名期刊发表SCI论文20余篇；主持、参加过国家自然科学基金委重点、面上、科技部973课题等十余项省部级以上基金研究工作。并担任《生物化学与分子生物学学报》编委，中国老年学和老年医学学会抗衰老分会常务委员。

2. 研究方向与领域：

主要研究方向：细胞衰老与肿瘤的分子机理研究。

从转录水平、蛋白质翻译后水平、信号转导、表观遗传等多个层次和角度揭示了一些转录因子、蛋白激酶以及非编码RNA在细胞衰老中发挥作用的分子机制，同时也对细胞衰老在食管癌、胰腺癌、结直肠癌发生发展的分子机制进行了探索。

3. 实验室成员：

4. 主要代表作：

（1）Ai Qing Yu, Zhi Xiao Wang, Wu Wu, Ke Yu Chen, Shi Rong Yan, Ze Bin Mao. Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2. Aging,2019,11:10220-10241.

（2）Yang J, Liu K, Yang J, Jin B, Chen H, Zhan X, Li Z, Wang L, Shen X, Li M, Yu W and Mao Z.PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311. Oncogene, 2017, 36: 4828-4842

（3）Wu CL, Wang Y, Jin B, Chen H, Xie BS, Mao ZB. Senescence-associated long non-coding RNA(SALNR) delays oncogene-induced senescence through NF90 regulation. J. Biol.Chem., 2015, 290: 30175-30192

（4）Liu K, Jin B, Wu C, Yang J, Zhan X, Wang L, Shen X, Chen J, Chen H, Mao ZB*. NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. Int. J. Biol. Sci., 2015, 11:762-771

（5）Jin B，Wang Y, Wu CL, Liu KY, Chen H, Mao ZB. Pim-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. Aging Cell. 2014 Oct; 13(5):879-89.

（6）Chenglin Wu, Bo Jin, Liting Chen, Dexiang Zhuo, Zheng Zhang, Kan Gong, ZebinMao. MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma. Cell. Signal. 2013, 25:1212-1221.

（7）Chen YC, Zhang XW, Niu XH, Xin DQ, Zhao WP, Na YQ and Mao ZB.Macrophage migration inhibitory factor is a direct target of HBP1-mediated transcriptional repression that is overexpressed in prostate cancer. Oncogene. 2010, 29:3067-3078.

（8）De Xiang Zhuo, Xiao Hua Niu, Yi Cheng Chen, Dian Qi Xin, Ying Lu Guo, and Ze Bin Mao. Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts. J.Biol.Chem. 2010, 285:31491-31501.

5. 联系方式:

毛泽斌

北京大学医学部生物化学与分子生物学系

Email:zbmao@bjmu.edu.cn

电话：010-82805138