1. 个人简介：

毛泽斌，教授，主要从事细胞衰老与肿瘤的分子机理研究。在Aging，Aging cell, Oncogene等国际知名期刊发表SCI论文20余篇；主持、参加过国家自然科学基金委重点、面上、科技部973课题等十余项省部级以上基金研究工作。并担任《生物化学与分子生物学学报》编委，中国老年学和老年医学学会抗衰老分会常务委员。

2. 研究方向与领域：

主要研究方向：细胞衰老与肿瘤的分子机理研究。

从转录水平、蛋白质翻译后水平、信号转导、表观遗传等多个层次和角度揭示了一些转录因子、蛋白激酶以及非编码RNA在细胞衰老中发挥作用的分子机制，同时也对细胞衰老在食管癌、胰腺癌、结直肠癌发生发展的分子机制进行了探索。

3. 实验室成员：

4. 主要代表作：

（1） Keyu Chen, Tiane Li, Honglin Diao, Qikai Wang, Xiaojia Zhou, Zhihua Huang ,Mingyue Wang, Zebin Mao, Yinmo Yang, Wenhua Yu. SIRT7 knockdown promotes gemcitabine sensitivity of pancreatic cancercell via upregulation of GLUT3 expression. Cancer Lett.,2024,598:217109

（2）Ai Qing Yu, Jie Wang, Xiao Jia Zhou, Ke Yu Chen, You De Cao, Zhi Xiao Wang, Ze Bin Mao. Senescent Cell-Secreted Netrin-1 Modulates Aging-Related Disorders by Recruiting Sympathetic Fibers. Front Aging Neurosci., 2020,12:507140.

（3）Li M, Yang J, Liu K, Yang J, Zhan X, Wang L, Shen X, Chen J, Mao Z.p16 promotes proliferation in cervical carcinoma cells through CDK6-HuR-IL1A axis. J. Cancer. 2020, 11: 1457-1467.

（4）Ai Qing Yu, Zhi Xiao Wang, Wu Wu, Ke Yu Chen, Shi Rong Yan, Ze Bin Mao. Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2. Aging,2019,11:10220-10241.

（5）Yang J, Liu K, Yang J, Jin B, Chen H, Zhan X, Li Z, Wang L, Shen X, Li M, Yu W and Mao Z.PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311. Oncogene, 2017, 36: 4828-4842

（6）Wu CL, Wang Y, Jin B, Chen H, Xie BS, Mao ZB. Senescence-associated long non-coding RNA(SALNR) delays oncogene-induced senescence through NF90 regulation. J. Biol.Chem., 2015, 290: 30175-30192

（7）Liu K, Jin B, Wu C, Yang J, Zhan X, Wang L, Shen X, Chen J, Chen H, Mao ZB*. NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. Int. J. Biol. Sci., 2015, 11:762-771

（8）Jin B，Wang Y, Wu CL, Liu KY, Chen H, Mao ZB. Pim-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. Aging Cell. 2014 Oct; 13(5):879-89.

（9）Chenglin Wu, Bo Jin, Liting Chen, Dexiang Zhuo, Zheng Zhang, Kan Gong, ZebinMao. MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma. Cell. Signal. 2013, 25:1212-1221.

（10）Chen YC, Zhang XW, Niu XH, Xin DQ, Zhao WP, Na YQ and Mao ZB.Macrophage migration inhibitory factor is a direct target of HBP1-mediated transcriptional repression that is overexpressed in prostate cancer. Oncogene. 2010, 29:3067-3078.

（11） De Xiang Zhuo, Xiao Hua Niu, Yi Cheng Chen, Dian Qi Xin, Ying Lu Guo, and Ze Bin Mao. Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts. J.Biol.Chem. 2010, 285:31491-31501.

5. 联系方式:

毛泽斌

北京大学医学部生物化学与分子生物学系

Email:zbmao@bjmu.edu.cn

电话：010-82805138