1. 个人简介：

近年来围绕转录因子和表观调控因子探究肿瘤发生发展的分子机制，以第一作者/通讯作者在Nature Communication, Cell Research, Nucleic Acids Research, PNAS等杂志发表论文10篇。获得国家自然科学优秀青年及面上项目、国家“万人计划”青年拔尖人才、北京市自然科学基金重点研究专题等10项资助。2016年“乳腺癌发生发展的表观遗传机制”获国家自然科学二等奖（第四完成人）。获中国发明专利授权2项。

2. 研究方向与领域：

肿瘤细胞的命运决定及调控

3. 实验室成员：

4. 主要代表作：（*为第一作者，#为通讯作者）

Ø Jianze Wang*, Qianrui Guo*, Lin He*, Rui Song, Jinhong Du, Haoyi Zhou, Yameng Hao, Xiujie Yang, Feng Wang, Kui Li, Mo Li, Zhi Yang, Luyang Sun#, Zhaofei Liu# (2025). A Nano-Radiosensitizer Potentiates Tumor Radiotherapy through JFK Inhibition and Hypoxia Alleviation. Nano Letters

Ø Lu Xia*, Jichuan Wang*, Hui Xue, Haimeng Li, Qinghua Li, Sen Qin, Chunyu Yu, Yanhua Liu, Yu Gao, Lingyun Li, Sudun Guan, Enrun Zheng, Feiya Suo, Lin He, Yongsheng Wang, Wenling Han#, Yongfeng Shang#, Yong Geng#, and Luyang Sun# (2025). A CMTM6 Nanobody Overcomes EGFR-TKI Resistance in Non-small Cell Lung Cancer. Advanced Science

Ø Yazi Yang*, Sen Qin*, Mengyu Yang, Ting Wang, Ru Feng, Chunli Zhang, Enrun Zheng, Qinghua Li, Pengyu Xiang, Shangyong Ning, Xiaodong Xu, Xin Zuo, Shuai Zhang, Xiaoya Yun, Xuehong Zhou, Yue Wang, Lin He, Yongfeng Shang#, Luyang Sun#, Hui Liu# (2024). Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy. Clinical Cancer Research 30:4201-14

Ø Sen Qin*, Yawei Xu*, Shimiao Yu, Wencong Han, Shiheng Fan, Wenxiang Ai, Kenan Zhang, Yizhou Wang, Xuehong Zhou, Qi Shen, Kan Gong#, Luyang Sun#, Zheng Zhang# (2024). Molecular Classification and Tumor Microenvironment Characteristics in Pheochromocytomas. eLife 12:RP87586.

Ø Lin He#, Yiping Cao, Luyang Sun# (2024). NSD Family Proteins: Rising Stars as Therapeutic Targets. Cell Insight 3 (2): 100151

Ø Lin He, Chunyu Yu, Sen Qin, Enrun Zheng, Xinhua Liu, Yanhua Liu, Shimiao Yu, Yang Liu, Xuelin Dou, Zesen Shang, Yizhou Wang, Yue Wang, Xuehong Zhou, Boning Liu, Yuping Zhong, Zhiqiang Liu, Jin Lu, and Luyang Sun# (2023). The Proteasome Component PSMD14 Drives Myelomagenesis through a Histone Deubiquitinase Activity. Molecular Cell 83(22):4000-4016

Ø Rui-Yuan Pan*, Lin He*, Jing Zhang, Xinhua Liu, Yajin Liao, Ju Gao, Yang Liao, Yuhan Yan, Qianqian Li, Xuehong Zhou, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun#, Zengqiang Yuan# (2022). Positive Feedback Regulation of Microglial Glucose Metabolism by Histone H4 Lysine 12 Lactylation in Alzheimer’s Disease. Cell Metabolism 34(4):634-648.e6. (ESI Highly Cited Papers; Highlighted by Nature Chemical Biology; Highlighted by Molecular Neurodegeneration)

Highlighted by Yiyun Song# (2022). A vicious cycle. Nature Chemical Biology 18, 434

Highlighted by Yingjun Zhao, and Huaxi Xu# (2022). Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease. Molecular Neurodegeneration 17, 36

Ø Xujun Liu*, Wenzhe Si*, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Cheng, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun# and Yongfeng Shang# (2021). The Existence of a Nonclassical TCA Cycle in the Nucleus that Wires the Metabolic-Epigenetic Circuitry. Signal Transduction and Targeted Therapy 6(1):375

Ø Ziran Yang*, Xuehong Zhou*, Enrun Zheng, Yizhou Wang, Xinhua Liu, Yue Wang, Yanpu Wang, Zhaofei Liu, Fei Pei, Yue Zhang, Jie Ren, Yunchao Huang, Lu Xia, Sudun Guan, Sen Qin, Feiya Suo, Jie Shi, Lijing Wang, and Lin He#, and Luyang Sun# (2021). JFK Is a Hypoxia-inducible Gene that Functions to Promote Breast Carcinogenesis. Frontiers in Cell and Developmental Biology 9:686737

Ø Lin He*, Ruorong Yan*, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun# (2021). SCFJFK Is Functionally Linked to Obesity and Metabolic Syndrome. EMBO Reports 22(7):e52036

Ø Xia Ting, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun# (2019). USP11 Acts as a Histone Deubiquitinase Functioning in Chromatin Reorganization during DNA Repair. Nucleic Acids Research 47(18):9721-9740 (Recommended by F1000)

Recommended by F1000: By Prof. Vitaly Citovsky and Prof. Ido Keren. https://connect.h1.co/article/736581402

Ø Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Chengjian Guan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Rong Liu, Luyang Sun# and Yongfeng Shang# (2018). Imbalance of the Reciprocally Inhibitory Loop between the Ubiquitin-specific Protease USP43 and EGFR/PI3K/AKT Drives Breast Carcinogenesis. Cell Research 28(9):934-951

Ø Xujun Liu*, Wenzhe Si*, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun# (2017). JMJD6 Promotes Melanoma Carcinogenesis through Regulation of the Alternative Splicing of PAK1, a Key MAPK Signaling Component. Molecular Cancer 2017 16:175

Ø Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun# (2017). ZNF516 Suppresses EGFR by Targeting the CtBP/LSD1/CoREST Complex to Chromatin. Nature Communications 8(1):691

Ø Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun#, and Yongfeng Shang# (2015). SCF(JFK) Is a Bona Fide E3 Ligase for ING4 and a Potent Promoter of the Angiogenesis and Metastasis of Breast Cancer. Genes &Development 29(6):672-85

Ø Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun#, and Yongfeng Shang# (2014). JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. PLOS Biology 12(3):e1001819

Ø Na Yu, Peiwei Huangyang, Xiaohan Yang, Xiao Han, Ruorong Yan, Hongti Jia, Yongfeng Shang, and Luyang Sun# (2013). MicroRNA-7 Suppresses EMT and Invasion of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Lysine Methyltransferase SET8. Journal of Biological Chemistry 288(27): 19633-42

Ø Lei Shi*, Luyang Sun*, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, Yongfeng Shang (2011). JMJD2B Coordinates H3K4/H3K9 Methylation and Promotes Hormonally Responsive Breast Carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America 108(18):7541-6

Ø Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao, and Yongfeng Shang (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. Journal of Biological Chemistry 286(6):4226-35

Ø Luyang Sun*, Lei Shi*, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang (2009). JFK, a Kelch Domain-containing F-box Protein, Links the SCF Complex to p53 Regulation. Proceedings of the National Academy of Sciences of the United States of America 106(25): 10195-10200 (Recommended by F1000)

Recommended by F1000: By Prof. Anindya Dutta. https://connect.h1.co/article/1162802

5. 联系方式 :

Email: Luyang_sun@hsc.pku.edu.cn