科研PI
孙露洋 教授
1. 个人简介：
孙露洋, 教授，博士生导师。近年来聚焦肿瘤细胞可塑性的表观遗传调控机制，在Cell Metabolism,STTT, Cell Research, Nature Communication, Nucleic Acids Research, PNAS等杂志发表论文14篇。获得国家自然科学优秀青年、国家“万人计划”青年拔尖人才、科技部重点研发子课题、北京市自然科学基金重点研究专题等十余项国家及省部级项目资助。2016年“乳腺癌发生发展的表观遗传机制”获国家自然科学二等奖（第四完成人）。获中国发明专利授权2项。
2. 研究方向与领域：
肿瘤细胞的命运决定及调控
3. 实验室成员：
4. 主要代表作：（*为第一作者，#为通讯作者）
（1）Rui-Yuan Pan*, Lin He*, Jing Zhang, Xinhua Liu, Yajin Liao, Ju Gao, Yang Liao, Yuhan Yan, Qianqian Li, Xuehong Zhou, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun#, Zengqiang Yuan#(2022). Positive Feedback Regulation of Microglial Glucose Metabolism by Histone H4 Lysine 12 Lactylation in Alzheimer’s Disease. Cell Metabolism(Inpress)
（2）Xujun Liu*, Wenzhe Si*, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Cheng, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun#and Yongfeng Shang# (2021). The Existence of a Nonclassical TCA Cycle in the Nucleus that Wires the Metabolic-Epigenetic Circuitry. Signal Transduction and Targeted Therapy 6(1):375
（3）Ziran Yang*, Xuehong Zhou*, Enrun Zheng, Yizhou Wang, Xinhua Liu, Yue Wang, Yanpu Wang, Zhaofei Liu, Fei Pei, Yue Zhang, Jie Ren, Yunchao Huang, Lu Xia, Sudun Guan, Sen Qin, Feiya Suo, Jie Shi, Lijing Wang, and Lin He#, andLuyang Sun# (2021). JFK Is a Hypoxia-inducible Gene that Functions to Promote Breast Carcinogenesis.Frontiers in Cell and Developmental Biology9:686737
（4）Lin He*, Ruorong Yan*, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, andLuyang Sun# (2021). SCFJFK Is Functionally Linked to Obesity and Metabolic Syndrome. EMBO Reports 22(7):e52036
（5）XiaTing, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun# (2019). USP11 Acts as a Histone Deubiquitinase Functioning in Chromatin Reorganization during DNA Repair. Nucleic Acids Research 47(18):9721-9740
（6）Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, JieRen, Yue Wang, Lin Shan,Chengjian Guan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Rong Liu, Luyang Sun# and Yongfeng Shang# (2018). Imbalance of the reciprocally inhibitory loop between theubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Research 28(9):934-951
（7）Xu jun , Wenzhe Si, Xinhua Liu, Lin He, JieRen, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun# (2017). JMJD6 Promotes Melanoma Carcinogenesis through Regulation of the Alternative Splicing of PAK1, a Key MAPK Signaling Component.Molecular Cancer 2017 16:175
（8）Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, GuojiaXie, BosenXu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun# (2017). ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nature Communication 8(1):691
（9）Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, GuojiaXie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun#, and Yongfeng Shang# (2015). SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes &Development29(6):672-685
（10）Feng Wang, Lin He, PeiweiHuangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun#, and Yongfeng Shang#(2014). JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation.PLOS Biology12(3):e1001819
（11）Lei Shi*, Luyang Sun*, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, ChenghaoXuan, Zhi Yao, Yongfeng Shang (2011). JMJD2B Coordinates H3K4/H3K9 Methylation and Promotes Hormonally Responsive Breast Carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America108(18):7541-7546
（12）Luyang Sun*, Lei Shi*, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang (2009). JFK, a Kelch Domain-containing F-box Protein, Links the SCF Complex to p53 Regulation.Proceedings of the National Academy of Sciences of the United States of America106(25): 10195-10200
5. 联系方式 :
电话：010-82801608
Email: Luyang_sun@hsc.pku.edu.cn