陈军，北京大学医学部基础医学院生物化学与分子生物学系副教授，博士生导师。先后主持4项国家自然科学基金面上项目并参与科技部“973”课题和重点研发计划等研究课题。在PNAS，Cell Death & Differ, Aging Cell, Aging等国际期刊发表衰老相关领域SCI论文10篇。

2. 研究方向与领域：

主要研究方向：细胞衰老的分子机制和小分子化合物对衰老的干预。

衰老的分子机制研究主要聚焦于衰老相关分泌表型（senescence-associated secretory phenotype, SASP）调控、端粒酶复合体组装和活性调节、p16等细胞衰老关键基因的表达调控、RNA结合蛋白在细胞衰老中的作用等方面。衰老的干预研究主要聚焦于小分子化合物在延缓机体衰老和预防衰老相关疾病中的作用。

3.实验室成员：

教工：陈军副教授（PI），韩丽敏副教授（Co-PI），李国栋副主任技师

学生：张娜、胡克新、刘豆豆、方志强

4．主要代表作：

（1）ChenzhongXu, Nan Xie, Yuanyuan Su, Zhaomeng Sun, Yao Liang, Na Zhang, Doudou Liu, ShuqinJia, Xiaofang Xing, Limin Han, Guodong Li, Tanjun Tong, Jun Chen*. HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation. Cell Death Differ. 2020 Jun; 27(6):1998-2013.

（2）Yao Liang, Yuanyuan Su, ChenzhongXu, Na Zhang, Doudou Liu, Guodong Li, Tanjun Tong, Jun Chen*. Protein kinase D1 phosphorylation of KAT7 enhances its protein stability and promotes replication licensing and cell proliferation. Cell Death Discovery. 2020 Sep 18; 6:89.

（3）Sun Zhaomeng, Zhao Lijun, Su Li, Fan Qing, XuChenzhong, Su Yuanyuan, Liang Yao, Li Guodong, XueYanxue, Tong Tanjun, Chen Jun*. Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice. Aging (Albany NY). 2019 May 2; 11(9):2583-2609.

（4）Su Yuanyuan, XuChenzhong, Sun Zhaomeng, Liang Yao, Li Guodong, Tong Tanjun, Chen Jun*. S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α. Aging (Albany NY). 2019 Jan 23; 11(2):549-572.

（5）Su Yuanyuan, Wang Pengfeng, Shen Hong, Sun Zhaomeng, XuChenzhong, Li Guodong, Tong Tanjun, Chen Jun*. Protein kinase D1-mediated classical protein secretory pathway regulates oncogene Ras-induced senescent response. J Cell Sci. 2018 Mar 16; 131(6). pii: jcs207217.

（6）Hui Wang, Limin Han, Ganye Zhao, Hong Shen, Pengfeng Wang, Zhaomeng Sun, ChenzhongXu, Yuanyuan Su, Guodong Li, Tanjun Tong* and Jun Chen*.hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability. Aging Cell (2016) 15, 1063–1073.

（7）Wang Pan, Han LiMin, Shen Hong, Wang PengFeng, LvCuiCui, Zhao GanYe, Niu Jing, XueLiXiang, Wang QimingJane, Tong TanJun*, Chen Jun*.Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation.ProcNatlAcadSci U S A. 2014 May 27;111(21):7683-8.

（8）Lijun Zhao#, Jianzhong Cao#, Kexin Hu, Penghui Wang, Guodong Li, Xiaodong He*, Tanjun Tong*, and Limin Han*, RNA-binding protein RPS3 contributes to hepatocarcinogenesis by post-transcriptionally up-regulating SIRT1. Nucleic Acids Research, 2019, Vol. 47, No. 4 2011–2028

（9）Lijun Zhao#, Kexin Hu#, Jianzhong Cao, Pan Wang, Jun Li, KewuZeng, Xiaodong He, Peng-FeiTu*, Tanjun Tong*, Limin Han*. lncRNAmiat functions as a ceRNA to upregulate sirt1 by sponging miR-22-3p in HCC cellular senescence. Aging (Albany NY). 2019, 11(17): 7098-7122.

5. 联系方式:

陈军

北京大学医学部生物化学与分子生物学系

电子邮件：cjbiochem@bjmu.edu.cn

办公电话：010-82802527