副教授与讲师

俞文华副教授
1. 个人简介:
俞文华,博士,北京大学医学部生物化学与分子生物学系,副教授,博士生导师,主要研究方向为肿瘤和衰老发生发展中的代谢及表观遗传机制。在国际主流期刊发表多篇研究论文,包括Nature Communications, Cancer Lett,Oncogene和Journal of Biological Chemistry等。作为课题负责人主持国家自然科学基金青年项目以及多项面上项目。曾获得基础医学院优秀论文奖及引用奖,作为参与人获得中华医学科技奖,自然科学一等奖等。作为参与人参编、翻译多本生化领域教材。
2. 代表性论文:
(1) ChenK,LiT, DiaoH,WangQ, ZhouX,HuangZ,WangM, Mao Z*,YangY*, YuW*. SIRT7 knockdown promotes gemcitabine sensitivity of pancreaticcancer cell via upregulation of GLUT3 expression, Cancer Lett., 2024, 28(598)
(2) Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, He L, LiW, Yi X, Sun L, Liang J, Cheng Z, Shi L, Shang Y*, Yu W*. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genomestability, Nature Communications, 2016, 7: 0-12235
(3) Yang J, Liu K, Yang J,Jin B, Chen H, Zhan X, Li Z, Wang L, Shen X, Li M, Yu W*, Mao Z*.PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311, Oncogene, 2017,36(34): 4828-4842
(4) Zhan X, Yang J, Mao Z, Yu W*.PIM1-catalyzed CBX8 phosphorylationpromotes the oncogene-induced senescence of human diploid fibroblast, Biochemical and BiophysicalResearch Communications, 2018, 501(3): 779-785
(5) ShenX, LiM, MaoZ*,YuW*. Loss of circadian protein TIMELESSaccelerates the progression of cellular senescence, Biochemical and Biophysical ResearchCommunications, 2018, 503(4): 2784-2791
3. 联系方式:
办公地址:北京大学医学部生化楼207
电话:010-82801434(办公室)
E-mail:yuwenhua@bjmu.edu.cn